Since then it made little impact in the market or headline until the 1992 when Dr. Weitraub from the Rochester school of medicine and dentistry published a study paper alluding that a cocktail with the Phentermine as the active agent by the brand name Fen-Phen was several times more effective than the traditionally thought weight loss panaceas which were the diet and exercises. Although FDA has approved both phentermine without prescription for weight loss and Fenfluramine, their cocktail “Fen-Phen” has since its inception been considered “off-label” by physicians. Another Phentermine cocktail is the drug Dexfen-Phen, whose only difference from the Fen-Phen is the ingredient dexfenfluramine or redux instead of Fenfluramine in case of Fen-Phen. It should be noted that Dexfenfluramine was the only one which was considered as a appetite suppressant until the cocktail Dexfen-Phen followed suit.